The Biscuits have four players on the Southern League's South Division All-Star roster.
First baseman Cameron Seitzer, outfielders Kevin Kiermaier and Mikie Mahtook and pitcher Enny Romero are on the list for the July 17 game, which will be played in Jacksonville, Fla.
Two Biscuits relievers were honorably mentioned.
C.J. Riefenhauser was eligible, but he was promoted to Triple-A Durham last weekend.
Though he's back with the Biscuits, Juan Sandoval wasn't eligible since he was with Durham when All-Star ballots were first distributed. A player had to be on a Southern League roster June 12 to be eligible for a vote.
Kiermaier has a league-high .317 average and is tied for second with 60 runs scored.
Romero is 8-3 with a 2.69 ERA, is 10th in the league in ERA and is also headed to the All-Star Futures Game on July 14 in New York.
Mahtook and Seitzer are the only players in the Southern League to have played in every game this year. Seitzer has a .275 average, is tied for the league lead with 21 doubles and has 36 RBIs and 35 runs scored. Mahtook is hitting .238 with a team-best 46 RBIs.
Riefenhauser and Sandoval have 11 saves each for the Biscuits. Riefenhauser was 4-0 with an 0.51 ERA in 34 appearances. Sandoval is 2-1 with a 2.76 ERA in 24 games.